Ataxia MJD.org. They Found the Gene. Let's Find the Cure.

Published Research on MJD

Although much of the published research about neurodegenerative diseases is difficult to fully comprehend, we are following it and will relay what we learn about it on this page. If you become aware of pertinent research, or are a scientist working on Machado-Joseph Disease, please let us know.

See the Research News page for information on recent discoveries and research we have funded.

We Move:
http://www.wemove.org
  

RNAi Therapies for MJD:
A New Improved Gene Therapy Can Be the First Treatment for Machado-Joseph Disease

Stem Cells for Cell-Based Therapies
http://www.actionbioscience.org/biotech/pecorino2.html

November 26th, 2008 issue of Journal of Neuroscience: Deranged Calcium Signaling and Neurodgeneration in Spinocerebellar Ataxia Type 3

February 1998 Proc. Natl. Acad. Sci. USA, pp. 1253-1258 This article discussed the potential of Insulin-like Growth Factor 1 (IGF-1) to induce recovery in an animal model of cerebellar ataxia. When rats rendered ataxic were treated with IGF-1, certain damaged neurons were rescued to various degrees, depending on the time that treatment with IGF-1 was started. The results of this research (according to the abstract) suggest that human ataxia could possibly be treated with IGF-1 by a simple procedure.
February '98 Proc. Natl. Acad. Sci. USA, pp 1253-1258 Citation

May 1998 Journal Neuropathol Exp Neurol, pp. 426-438 NIH study about the promising potential of IGF-1 in treating Multiple Sclerosis.
May '98 Journal Neuropathol Exp Neurol, pp. 426-438 Citation

June 12, 1998 Cell (6): 939-949 MJD researchers, Drs. Paulson, Warrick, Bonini et. al. have created a fly model of MJD, which according to Paulson, should help them identify relevant modifying genes. This may lead to therapies in the future.
June 12, '98 Cell Citation

July 27, 1998 Press Release Production of Nerve Growth Factors Leads to Functional Improvement in the Brain Which May Provide Therapeutic Benefit in Battle Against Neurodegenerative Diseases
NeoTherapeutic Press Release

Elan Corporation Breakthrough in Alzheimer's Disease Research - see Elan's Web Site

Cephalon is another company that is working on drugs for neurodegenerative diseases. Article about Cephalon's new drug

Current Clinical Research Projects of Parkinson's Disease Center and Movement Disorder Clinic

Muscular Dystrophy Association Gene Therapy Search National Library of Medicine at NIH for Machado and Joseph

Search National Library of Medicine at NIH for SCA3

National Institutes of Health Search & Browse Page

FDA drug approval information

 
 
 
Copyright © 2012 Ataxia MJD Research Project, Inc.
Send mail to info@ataxiamjd.org with your questions and comments.